Crioterapie cu azot lichid

-Liquid nitrogen cryotherapy




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What is liquid nitrogen cryotherapy? What is the procedure?

Liquid nitrogen cryotherapy is a commonly used therapeutic method in dermatology for the controlled destruction of benign, premalignant and malignant skin lesions.

Liquid nitrogen is found at -196 degrees Celsius, applied to the skin, reaches -40 - 50 degrees, which is the optimal temperature to destroy the treated lesion.

The procedure consists of applying liquid nitrogen to skin lesions using the Cryoset MC-150 applicator, with application tips of different shapes and sizes, depending on the type and size of the lesions. After the application of liquid nitrogen, intra- and extracellular ice crystals are formed which leads to cell lysis (necrosis) and the induction of an immune response against the cells.

Cryotherapy does not usually require local anesthesia and the procedure itself takes a few seconds, depending on the size and depth of the lesion.

Sometimes the application is repeated after the thawing is complete. This technique is known as "double freeze-thaw" and is usually used for more resistant skin lesions.

What are the side effects or complications after cryotherapy?

-local burning sensation or pain during nitrogen application and a few seconds after the end of treatment

-local inflammation (redness and swelling) that can occur from a few minutes to 12-24 hours after treatment

-the formation of blister or blister, with clear or hemorrhagic fluid that will come off spontaneously from the healthy tissue in about 5-7 days, the healing period being usually painless.

-after about 7 days from the treatment, a crust may appear on the treated area, which will come off on its own after 7-21 days, depending on the treated area.

-superinfection is very rare, manifested by pain, swelling, redness, purulent discharge around the treated area

-skin healing can sometimes be done with a slight change in color (hypo- or hyperpigmentation)

atrophic scars can occur very rarely, followed by deep or prolonged freezing

How should the treated area be cared for after the procedure?

Usually, no treatment is needed during the healing phase. Delicate daily local toileting of the treated area is recommended. The dressing is optional, but may be necessary if the affected area is injured.

If a bubble appears, its liquid is removed by puncturing the bubble with a sterile needle. On the ontraindi area, apply a local antiseptic, then apply a sterile dressing.

When is liquid nitrogen cryotherapy indicated?

Cryotherapy is indicated in various skin lesions such as vulgar warts, viral papillomas, acrochordons, seborrheic keratoses, actinic keratoses, genital warts, molluscum contagiosum, hypertrophic scars, sebaceous gland hyperplasia, angiomas, etc. In some situations, when surgical excision is contraindicated due to comorbidities, it can be used to treat early, superficial skin cancers, such as basal cell carcinomas and Bowen's disease.

What are the benefits of cryotherapy?

-is a quick method (usually takes about 30 seconds for each lesion, depending on their type and size) and easy to apply

-does not require anesthesia, the discomfort being minimal

-ideal for patients with multiple lesions or allergies to local anesthesia and for those at significant surgical risk due to comorbidities

-can be performed even in children and pregnant women

What are the disadvantages of cryotherapy?

-may sessions may be required, at an interval of 10-14 days, depending on the size of the lesions

-can be accompanied by a slight pain, more often in areas with thick skin (palms, soles or fingertips)

What are the contraindications to the procedure?

Cryotherapy is contraindicated in patients with cryoglobulinemia, cryofibrinogenemia, cold urticaria, cold intolerance. It is also contraindicated in lesions that require histopathological examination for diagnosis and for recurrent non-melanocytic skin cancers.